an in-vitro iontophoretic permeation study of nicotine through rat skin

نویسندگان

a momajjad

چکیده

nicotine transdermal systems are being used as an aid to smoking cessation programs. as the kinetics of nicotine delivery is important in success of a smoking cessation program, rapid and high input of nicotine is required, which is not possible by passive methods and requires enhancement strategies such as iontophoresis. iontophoretic permeation, of nicotine looks promising, based on published data on human skin. however, to optimize this method, permeation pathways should be known and further parameters have to studied, which are the subject of the present investigation. in this study iontophoretic permeation of nicotine through rat skin was performed and the effects of different variables on this phenomenon were studied. anodic iontophoresis of nicotine from a solution at ph 2.8, using a 0.5 ma/cm2 current density resulted in a considerable enhancement (about 3-fold) of nicotine absorption through rat skin. nicotine concentration and current density showed a directly increasing effect on permeation of the drug, but the effect of concentration was not linear. pulsatile current delivery was more effective in permeation of nicotine than the continuous method. anodic iontophoresis was around 2-fold more effective than the cathodic method in increasing the flux. post iontophoretic permeation studies showed good reversibility of the membrane barrier properties. results were in good agreement with the reported human data and might be considered as an evidence of the ability of rat skin to model human skin and also the importance of intercellular pathway of the stratum corneum in iontophoretic delivery of nicotine and possibly other drugs. donor&apos;s ph showed no effect on permeation of nicotine under the studied conditions, ph values of <3. results also showed that the electr-osmotic flow could occur at ph values lower than 4. finally, this study show that by controlling the effective parameters of iontophoretic delivery, a more effective nicotine transdermal delivery method would achievable.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An In-Vitro Iontophoretic Permeation Study of Nicotine through Rat Skin

Nicotine transdermal systems are being used as an aid to smoking cessation programs. As the kinetics of nicotine delivery is important in success of a smoking cessation program, rapid and high input of nicotine is required, which is not possible by passive methods and requires enhancement strategies such as iontophoresis. Iontophoretic permeation, of nicotine looks promising, based on published...

متن کامل

An In-Vitro Iontophoretic Permeation Study of Nicotine through Rat Skin

Nicotine transdermal systems are being used as an aid to smoking cessation programs. As the kinetics of nicotine delivery is important in success of a smoking cessation program, rapid and high input of nicotine is required, which is not possible by passive methods and requires enhancement strategies such as iontophoresis. Iontophoretic permeation, of nicotine looks promising, based on published...

متن کامل

Influence of Chemical Permeation Enhancers on the in vitro Skin Permeation of Minoxidil through Excised Rat Skin: A Mechanistic Study

Abstract: Minoxidil, a pyrimidine derivative (2, 4-diamino-6-piperidinopyrimidine-3-oxide) is the only topical medical treatment with proven efficacy for the treatment of Androgenetic alopecia that shown low skin penetration and bioavailability. The main aim of this research was to investigate the effect of some permeation enhancers on the in vitro skin permeability of minoxidil . Minoxid...

متن کامل

Effect of Different Carriers on in vitro Permeation of Meloxicam through Rat Skin

The ability of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, polyvinyl pyrrolidone and urea to influence the percutaneous absorption of meloxicam through isolated rat skin was evaluated. Carrier complex were prepared by kneading method in 1:1 and 1:2 in molar ratios for β-cyclodextrin and hydroxypropyl-β-cyclodextrin and in 1:1, 1:3 and 1:5 in weight ratios for polyvinyl pyrrolidone and urea. T...

متن کامل

Acyclovir permeation through rat skin: mathematical modelling and in vitro experiments.

The aim of this work is to characterise the skin permeation properties of a male rat by means of a purely diffusive mathematical model based on Fick's second law. Additionally, in the attempt of proposing a reliable tool allowing the skin permeability (or resistance) determination on the basis of experimental data, the model automatically accounts also for two typical experimental conditions. I...

متن کامل

In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations

Objective(s): The purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. Materials and Methods: Niosomes were prepared by Thin Film Hydration (TFH) or Hand Shaking (HS) method. Propranolol niosomes were pre...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۲۰۰۵، شماره ۴، صفحات ۲۱۳-۲۱۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023